Accelerating next-generation drug discovery with click-based construction of PROTACs

In 2001, chemists K. Barry Sharpless, Hartmuth C. Kolb, and M. G. Finn introduced click chemistry, a concept in which organic ...
Nature

A general ligand design for gold catalysis allowing ligand-directed anti-nucleophilic attack of alkynes

Most homogenous gold catalyses demand ≥0.5 mol% catalyst loading. Owing to the high cost of gold, these reactions are unlikely to be applicable in medium- or large-scale applications. Here we disclose ...
JSTOR Daily

Highly Enantioselective Alkyne Additions to Aldehydes in the Presence of 1,1′ -bi-2-Naphthol and Hexamethylphosphoramide

This is a preview. Log in through your library . Abstract It is found that the addition of hexamethylphosphoramide to the solution of an alkyne, Et 2 Zn, and (S)-1,1′-bi-2-naphthol in methylene ...