C&EN

Small molecule activates key kinase

For decades, scientists have fought cancer by developing small molecules to inhibit kinase enzymes. These enzymes play an important role in a host of cellular processes, including phosphorylation and ...
TMCnet

Kanazawa University research: High-speed AFM imaging reveals how brain enzyme forms dodecameric ring structure

Using high-speed atomic force microscopy (HS-AFM), the Kanazawa University team led by Mikihiro Shibata filmed the dynamic movements of CaMKII at the single-molecule level. The images revealed that a ...

A short-lived kinase state that's essential for normal cell migration and T-cell function

Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src ...
Devdiscourse

PathGennie enables unbiased simulation of rare molecular events, boosting drug discovery

In the pharmaceutical discovery process, understanding a drug’s residence time—the duration a molecule remains bound to its ...
News-Medical.Net on MSN

Hidden kinase state enables rapid and repeated protein phosphorylation

Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows the kinase to repeatedly modify its ...
Clinical Trials Arena on MSN

Ipsen’s ultra-rare bone disease drug flops in Phase II trial

Ipsen’s failure comes shortly after Regeneron’s FOP study met its endpoints, sparking an FDA approval submission.