Modifications made during metabolic engineering for overproduction of chemicals have network-wide effects on cellular function due to ubiquitous metabolic interactions. These interactions, that make ...

Orthogonality is a concept often used to describe modular and maintainable software, but it’s more easily understood by way of a case study. In this article, Jens Dietrich demystifies orthogonality ...

The term orthogonality derives from the study of vectors. Most likely you have run across the term in basic trigonometry or calculus. By definition, two vectors in a plane are orthogonal when they are ...

In mathematical circles, the word ‘orthogonal’ is used to define relations or objects that are non-overlapping, uncorrelated or independent. This definition is highly relevant when referring to ...

A classification model is easiest to analyze when it has a balanced design. Many of the nice features of balanced designs are retained by error-orthogonal designs, which were introduced in a recent ...

Cox & Reid (1987) proposed the technique of orthogonalizing parameters, to deal with the general problem of nuisance parameters, within fully parametric models. They obtained a large-sample ...