We retrospectively studied records from patients participating to various prospective clinical trials on CPT-11 in which pharmacokinetic monitoring was involved; the full clinical profiles are ...

Radiation Therapy for Intracranial Germinoma: Results of the German Cooperative Prospective Trials MAKEI 83/86/89 PURPOSE: To determine the safety, pharmacokinetics, and pharmacodynamic effect of 2-[4 ...

Ten subjects received continuous, intravenous infusion of higenamine at gradually escalating doses from 0.5 to 4.0 μg·kg −1 ·min −1, each dose was given for 3 min. Blood and urine samples were ...

PTK787/ZK 222584 (PTK/ZK) is an oral angiogenesis inhibitor targeting all known vascular endothelial growth factor (VEGF) receptor tyrosine kinases, including VEGFR-1/Flt-1, VEGFR-2/KDR, VEGFR-3/Flt-4 ...

Background. Posaconazole is a triazole with anti-Aspergillus activity. However, little is known about the utility of posaconazole as primary therapy for invasive pulmonary aspergillosis. Methods. An ...

Minimum inhibitory concentrations (MICs) can be very useful in selecting the best antimicrobial agent for a given patient with known culture and susceptibility results. However, to do so effectively, ...

Explore our campus, meet lecturers and current students, and learn more about what it's like to study at Manchester. Qualify as a mathematical modeller with key skills in computational approaches in ...

This 4-day course is focused on presenting concepts related to the PK and PK/PD evaluation of therapeutic proteins. It will introduce participants to basic principles in the pharmacokinetic and ...

An integrated evaluation of the pharmacodynamic and pharmacokinetic properties of a drug is essential for successful translation to the clinic. However, cost-effective methods to measure these ...

RALEIGH, NORTH CAROLINA / ACCESS Newswire / October 8, 2025 / Belhaven Biopharma, a leader in developing innovative intranasal products for emergency use, today announced that the U.S. Food and Drug ...

In drug discovery, various parameters need to be established in preclinical trials before a pharmaceutical is approved for initial testing on human subjects. Pharmacokinetics is a field of study which ...