The tumor microenvironment (TME) consists of mediators surrounding a tumor, including diverse cell types, blood vessels, and ...

Immunotherapy has revolutionized cancer care by training the immune system to detect and destroy tumors. For many patients, ...

Scientists from A*STAR Institute of Molecular and Cell Biology (A*STAR IMCB) have identified the specific cells responsible ...

Metabolic reprogramming in the tumor microenvironment shapes immune function and therapy resistance, offering insights into ...

Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized hematologic cancer treatment, but its efficacy in solid tumors remains limited by poor infiltration into the complex tumor ...

Creating physiologically relevant conditions for cells that replicate in vivo environments can improve experimental results, ...

Cancer plasticity refers to the remarkable ability of cancer cells to alter their identity, function, and behavior in response to environmental stressors or therapeutic pressures. This dynamic trait ...

Circulating tumor cells were first described in 1869 by Thomas Ashworth, an Australian pathologist who observed them in a peripheral blood sample taken from a patient with metastatic cancer. 1 They ...

Existing oncology therapeutics are either so specific they can target only part of a tumor, or so generalized they kill healthy tissue. A new “Tumor Activated Therapy™” in development at the small ...

Scientists at École Polytechnique Fédérale Lausanne (EPFL), and at UNIL-CHUV, University Hospital Lausanne (CHUV) and University of Lausanne (UNIL) have developed a computational method to create ...