Watch the best plays by the San Francisco 49ers against the Indianapolis Colts in Week 16 of the 2025 NFL season. San Francisco 49ers quarterback Brock Purdy was named NFC Offensive Player of...

2 days ago · Find news, video, standings, scores and schedule information for the San Francisco 49ers.

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Dec 14, 2025 · Breaking San Francisco 49ers news and in-depth analysis from the best newsroom in sports. Follow your favorite clubs. Get the latest injury updates, player news and more from around …

3 days ago · The San Francisco 49ers moved one step closer to NFC supremacy Monday night, defeating the Indianapolis Colts on Monday Night Football to improve their record to 11-4 on the …

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Visit ESPN for San Francisco 49ers live scores, video highlights, and latest news. Find standings and the full 2025 season schedule.

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After his five-touchdown performance on Monday night, even longtime skeptics like former NFL star Kurt Warner are taking notice of what separates him from the pack. The San Francisco 49ers are...